The Skinny on GLP-1s and Other Weight Loss Drugs

weight loss medications, particularly GLP-1 receptor agonists, have gained significant attention for their potential to help individuals manage obesity. However, it is crucial to remember that regardless of any medication taken, maintaining a regular exercise and strength training routine is essential. Exercise helps in keeping the weight off, building strength and lean muscle, and promoting healthy aging. In this first part of our series, we will explore what GLP-1s and other weight loss drugs are, how they work, and their potential benefits.

What Are GLP-1 Receptor Agonists?

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications that mimic the GLP-1 hormone, which is involved in blood sugar regulation and appetite control. Examples include liraglutide (Saxenda, Victoza) and semaglutide (Ozempic, Wegovy).

How Do They Work?

GLP-1 receptor agonists help promote weight loss through several mechanisms:

  • Appetite Suppression: These drugs reduce hunger and increase feelings of fullness, helping individuals eat less.
  • Slowed Gastric Emptying: They slow down the emptying of the stomach, prolonging the feeling of fullness after meals.
  • Improved Insulin Sensitivity: By enhancing the body’s response to insulin, GLP-1s help regulate blood sugar levels more effectively.

Other Weight Loss Medications

Apart from GLP-1s, other medications are also used for weight loss:

  • Orlistat (Alli, Xenical): Works by inhibiting the absorption of fats from the diet.
  • Phentermine-topiramate (Qsymia): A combination drug that suppresses appetite and increases energy expenditure.
  • Bupropion-naltrexone (Contrave): A combination that affects appetite and the reward system related to eating.

The Benefits

Research shows that GLP-1 receptor agonists and other weight loss drugs can lead to significant weight loss when combined with lifestyle modifications such as a healthy diet and regular exercise. Studies have demonstrated weight loss of up to 15% of body weight with some GLP-1s.

Understanding the various options available for weight loss medication can empower you to make informed decisions. However, these medications should be part of a broader approach that includes diet and exercise for optimal results. If you’d like help getting started with a workout program book a free consultation with my team here.

Stay tuned for Part 2, where we will delve into the risks and unknowns associated with weight loss drugs, providing a balanced view of their potential side effects and long-term safety concerns.

Stay strong,




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